Viromer® RED has been extensively optimized for binding of large oligonucleotides such as mRNA and plasmids. By using the innovative Viromer® technology excellent delivery of mRNA and plasmid transfection complexes into standard cells like HEK-293, HeLa and CHO as well as in challenging cells such as C2C12 myoblasts and primary cells of macrophages, keratinocytes and pancreatic tumor cells is achieved. Combined with an active endosome escape
mechanism and a great safety researchers get unsurpassed mRNA and plasmid transfection efficacy. Very high plasmid transfection efficiency up to 80% can be achieved in primary human macrophages. Based on the fact that primary keratinocytes are predestinated to prevent uptake of any material an outcome of 65% plasmid transfection efficiency in these challenging cells by using Viromer® RED is a fantastic result. Please have a look to our extensive cell-data-base
which includes all cell types where transfection using Viromer® results in an efficiency of mRNA/plasmid transfection up to 90%.